Primary information |
---|
ID | antitb_1283, |
Name | 25759383 |
N-Terminal modification | Inhibitor 12 |
C-Terminal Modification | W-(boroMet) |
Chemical Modification | Addition of N-(2-(3,5-Difluorophenyl)acetyl) |
Linear/Cyclic | Free |
Length | boroMet = methionine boronic acid |
Chirality | Linear |
Nature | 2 |
Source | L |
Species | Synthetic |
Strain | substrate-based boronate inhibitors |
Inhibition Concentration | Mycobacterium tuberculosis |
In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv |
Cell Line | MIC50 = 12 μM |
Inhibition Concentration | In vitro |
Sequence | 2015 |
Cytotoxicity | Myeloma cells (MM1.S) |
In vivo Model | NA |
Lethal Dose | No cytotoxicty |
Immune Responce | None |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | Inhibit ClpP1P2 peptidase activity and protein degradation in the presence of ClpC1 and ClpX ATPases. |
Other activities | ClpP1P2 peptidase |
PMID | None |
Year of Publication | None |
Tertiary Structure (Technique) | Not Predicted), |
Primary information |
---|
ID | antitb_1284, |
Name | 25759383 |
N-Terminal modification | Inhibitor 12 |
C-Terminal Modification | W-(boroMet) |
Chemical Modification | Addition of N-(2-(3,5-Difluorophenyl)acetyl) |
Linear/Cyclic | Free |
Length | boroMet = methionine boronic acid |
Chirality | Linear |
Nature | 2 |
Source | L |
Species | Synthetic |
Strain | substrate-based boronate inhibitors |
Inhibition Concentration | Mycobacterium smegmatis |
In Vitro/ In vivo | Mycobacterium smegmatis strain constitutively expressing GFP-ssrA |
Cell Line | MIC50 = 12 μM |
Inhibition Concentration | In vitro |
Sequence | 2015 |
Cytotoxicity | Myeloma cells (MM1.S) |
In vivo Model | NA |
Lethal Dose | No cytotoxicty |
Immune Responce | None |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | Inhibit ClpP1P2 peptidase activity and protein degradation in the presence of ClpC1 and ClpX ATPases. |
Other activities | ClpP1P2 peptidase |
PMID | None |
Year of Publication | None |
Tertiary Structure (Technique) | Not Predicted), |